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Publication: Gregori C. et al. Efg1 Controls caspofungin-induced ...

Publication: Hnisz D et al. The Set3/Hos2 Histone Deacetyl ...

Publication: Hnisz D et al. Transcriptional loops meet ch...

Publication: Rockwell NC et al. ABC transporter Pdr10 regulat...

Publication: Bourgeois C et al. In vitro systems for studying...

Publication: Frohner IE et al. Candida albicans cell surface...

Main Research Interests

Karl Kuchler
Karl Kuchler
My group currently emphasizes two main areas that are related in terms of model organisms and topics.

First, we are dissecting the molecular mechanisms of selected eukaryotic ATP-binding Cassette (ABC) transporters. In particular, we are studying their role in stress signaling in yeast and in fungal pathogens of medical importance. We are also interested to delineate the mechanisms underlying clinical antifungal drug resistance development, and we study transcriptional networks that control drug resistance and stress response in Candida albicans and baker's yeast.

Second, host-pathogen relationships represent a new area of intense research interest, particularly the determinants of fungal virulence and pathogenicity.

A third major project on mammalian ABC proteins which started in 2005. Hence, within the next 3 years, my laboratory shall pursue several main research topics supported by personnel as indicated.

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Karl Kuchler Laboratory, Medical University Vienna, Max F. Perutz Laboratories, Department of Medical Biochemistry,
Dr. Bohr-Gasse 9/2, A-1030 Vienna, AUSTRIA, [T] +43/1/4277-61806, [F] +43/1/4277-9618, [E] karl.kuchler@meduniwien.ac.at